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Key Takeaways for Providers Standard GLP-1 therapies are highly effective for appetite regulation but often fail to address metabolic adaptation, leading to weight loss plateaus

Besides suppressing oxidative stress from abnormal neurotransmitter activity, NAC also reduces brain inflammation Besides suppressing oxidative stress from abnormal neurotransmitter activity, NAC also reduces brain inflammation (neuroinflammation)

Zhang Y, Zhang Y, Shi X, Han J, Lin B, Peng W, et al

In the AMPLITUDE-O post-hoc analysis, the HR for MACE was 0.70 (95% CI 0.371.30) with baseline SGLT2is and 0.74 (95% CI 0.580.94) without SGLT2is ( P -value for interaction 0.70), and the HR for HHF was 0.23 (95% CI 0.050.97) with SGLT2is and 0.70 (95% CI 0.421.17) without SGLT2is ( P -value for interaction 0.35) [47]