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Moreover, in many national health systems, obesity pharmacotherapy is prescribed in specialist obesity services [114]

These mechanisms are reported in available scientific literature and are presented for informational purposes only, within a research context

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353 These findings confirm that in the synovium, GLP-1R is expressed on two different cell types, macrophages and fibroblast-like synoviocytes, which are specialized cells distributed within the synovial intima and subintima, and these cell types play important roles in hyaluronic acid synthesis, metabolite processing, and clearance of matrix degradation fragments