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Cuproptosis in cancer: biological implications and therapeutic opportunities

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SUMMARY The invention provides small molecule mimetics (mimic) of the growth factor "hepatocyte growth factor" (HGF) that are orally active, display profound growth factor activity, and are inexpensive to synthesize

Mechanistically, BRD4770 inhibits mono-, di-, and tri-methylation of histone H3 at lysine 9 (H3K9me1/2/3), thereby reactivating key ferroptosis defense pathways, including the System Xc-GPX4 axis, the FSP1-CoQ10 axis, and the GTP cyclohydrolase 1 (GCH1)-BH4 pathway