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Topical Rapamycin works at the cellular level to reduce visible signs of aging and restore healthy texture and tone

relatively large apparent volume of distribution of ~2-3 L/kg in horse, cows, sheep & dogs reflecting its relatively high lipid solubility in dogs, xylazine is metabolized by the liver to ~20 metabolites, with only 8% eliminated unchanged in the urine, (Rector et al, 1996

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It can be considered as a promising approach for skin rejuvenation with excellent short-term results and well tolerability [109]