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Cagrilintide is the long-acting amylin analog that Novo Nordisk pairs with semaglutide in CagriSema the combination that produced up to 22.7% weight loss in the REDEFINE-1 Phase 3 trial

Analogous to the -glucuronidase linker, the dissociation mechanism involves hydrolysis of the -galactosidase moiety, which confers hydrophilicity to the chemical precursor

Furthermore, the optimal timing and sequencing of SFN administration in combination therapies require careful consideration