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gingivalis synergistically regulates three core pathways via the TLR4/NF-B signaling pathway: (1) iron metabolism imbalance (upregulation of TFRC and NCOA4 expression leading to intracellular iron overload), (2) lipid metabolism reprogramming (enhanced ACSL4 and LPCAT3 activity promoting polyunsaturated fatty acid phospholipid accumulation), (3) antioxidant defense collapse (downregulation of SLC7A11 and GPX4 triggering glutathione depletion and impaired lipid peroxide clearance)
Studies dating all the way back to the 1950s suggest that there may be a link between vitamin B12 and acne
Similar content being viewed by others Background During foodborne Salmonella enteritidis infection pathogens can pass the gut epithelial cell lining and translocate to extra-intestinal organs like the spleen and liver[1]
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