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Taking into account available data concerning the alkylating nature of ethylene oxide, the demonstration of DNA adducts, the overwhelming positive in vivo responses in mutagenic and clastogenic assays, the reproducible positive carcinogenic findings in animals, and the epidemiological findings suggesting an increase in the incidence of human cancer, ethylene oxide should be considered as a probable human carcinogen, and its levels in the environment should be kept as low as feasible