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The mechanisms that may contribute to the induction of oxidative damage in diabetic patients include hyperglycemia-induced glucose auto-oxidation, non-enzymatic glycation of proteins and lipids, increased sorbitol pathway activity, oxidation of AGEs, and formation of prostaglandin H2 (PGH2) [311]

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When your B12 is low, you might feel: Tired all the time, even after sleeping well Mentally foggy, with trouble concentrating Dizzy or lightheaded Depressed or anxious Your energy drops, and basic tasks can start to feel overwhelming