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However, due to the essential nature of iron for many biological processes, chelation therapy is typically reserved for preventing iron overload in patients requiring frequent blood transfusions, such as those with sickle cell disease and thalassemia [229]

In addition, there is evidence that pioglitazone reduces the risk of MI and acute coronary syndrome in patients with cardiovascular diseases (CVD) and patients with type 2 diabetes who had previous myocardial infarction [220,221,222]

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