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Despite low sequence similarity, all these proteins share a common BtrG-fold, conferring a high degree of structural conservation (Kumar et al., 2015)

Horvath, 2009)

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Solutions: Extend trial to 6 months before concluding inefficacy (some benefits take longer), increase dosing within safe ranges if using lower end, switch peptides (try Cerebrolysin if using BPC-157, or vice versa), add comprehensive eye exam to rule out progression versus peptide failure, consider peptides preventing worsening rather than producing improvement, discontinue if truly no benefit after 6 months rigorous trial