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Another priority is distinguishing pack sizes and product variants without using prohibited modified-risk descriptors or unsupported health claims

Introduction Despite being the leading cause of preventable death, nicotine dependence is a worldwide epidemic, and tobacco continues to be exploited by hundreds of millions of people around the world (1)

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88 In addition, the autoimmune response to elastin fragments, which develops after chronic tobacco smoking, points to a certain immunogenic activity of elastin-degradation products on DC-mediated adaptive immunity