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In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different

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Caution is also warranted in patients with severe renal impairment or GI disorders such as gastroparesis

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We co-expressed twin-strep-FLAG (TSF) tagged-DET1 and MBP-Ube2e1-3, as well as GST-tagged COP1 and MBP-Ube2e1-3 (Fig

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The name describes its molecular structure, a chain of three amino acids bound to a copper ion

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