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Materials and methods Intervertebral disc specimens Normal intervertebral disc tissues were collected from five patients: four males and one female

However, 24 patients did not complete the 90-day period due to various reasons: two patients started other intranasal medications, five voluntarily withdrew, nine were excluded by researchers for non-compliance, seven were lost to follow-up, and one patient died

The mean changes from baseline of Hb A 1c at d 28, and d 56 were: 0.16% 0.07 (1.71 mmol/mol) and 0.21% 0.09 (2.24 mmol/mol) for the ARA 290 group and 0.01% 0.07 (0.14 mmol/mol) and +0.21% 0.08 (+2.24 mmol/mol) for the placebo groups respectively (Figure 1