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Osteoporosis : Nicotine damages bone-forming cells and accelerates bone loss

After a lengthy discussion, the Gemara in Chullin 9b-10a concludes with the famous phrase, chamira sakanta meiisura, meaning that halachah is more stringent when it comes to physical danger than it is with other matters

As a rough guide, around 10 to 15 vape puffs are broadly comparable to one cigarette, since a cigarette is smoked in about that many puffs