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Track testosterone, estradiol, liver enzymes, hematocrit, and inflammatory markers

Non-steroidal anti-inflammatory drugs (NSAIDs), statins, glucocorticoids and monoclonal antibodies (e.g., targeting IL-6, TNF-, IL-12/23) have been reported to show moderate anti-depressant capacity in patients with somatic disorders (i.e., rheumatoid arthritis, psoriasis) who also had comorbid symptoms of depression [194, 195]

For those managing a confirmed deficiency rather than simply maintaining levels, the treatment approach shifts significantly

Most of the benefit fades once you stop, because these therapies manage a condition rather than cure it