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These agents indirectly inhibit fluid volume increases by inhibiting angiotensin IIstimulated release of aldosterone

In lab tests, BPC-157 also increased endothelial-cell migration and capillary-like tube formation, showing its role in angiogenesis through activation of the VEGF and ERK pathways

Therefore, we performed pharmacokinetic studies of BPC157 in beagle dogs following single IV administration at a dose of 6 g/kg, single IM administration at doses of 6, 30, or 150 g/kg, and repeated IM administration at a dose of 30 g/kg for seven consecutive days