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As detected by DCFH-DA and C11-BODIPY staining of frozen sections of the PDX tumors, the ROS levels and lipid peroxidation levels of the PDX tumors with high ACTL6A expression were lower, and they were significantly increased by BSO treatment

This indicates that stimulating GSH production, which has been shown to prevent degeneration of RPE cells 70 , could potentially serve as an intervention strategy to combat ROS in maturing mouse retinas with RP where all rods have degenerated

JASPAR database analysis revealed a high-affinity PPARa binding motif within the FSP1 promoter

In turn, this can lead to better fat loss over a shorter amount of time