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(72) reported in a randomized controlled trial that the Yiqi Yangyin Huoxue formula combined with acupuncture lowered IL-1, IL-17, and serum amyloid A (SAA) levels, and improved blood glucose and renal function, indicating a synergistic effect with core acupoints such as ST36, SP6, and BL23

Conceptual Origin: From Empirical Observation to Theoretical Framework In the 16th century, the Swiss physician Paracelsus established the philosophical foundation for dose-response relationships with his statement, The dose makes the poison ( Sola dosis facit venenum )