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Intestinal-Inflammation Research: BPC-157 is studied in preclinical models of inflammatory gastrointestinal conditions

Proc Natl Acad Sci USA 98 : 1172511730

H., Huang, S

Indirectly, a third mechanism of action could be considered since ghrelin decreases plasma levels of IGF-I, consequently inhibiting the negative effect of IGF-I on GH secretion exerted directly on the somatotrophs, and indirectly because IGF-I induces hypothalamic secretion of SS (2) ( Figure 4A )