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doi: 10.1039/D3RA00723E 88 HamsaN.YogeshG

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In the present study we have examined GSH changes using the most common rodent exposure regimen for chronic CS studies and have shown that there is a GSH adaptive response to CS that occurs very early on and can be maintained for periods of up to 4 months

Cellular defenses against oxidative stress predominantly rely on the nuclear factor erythroid 2-related factor 2 (Nrf2), which orchestrates the expression of various antioxidant proteins and detoxification enzymes, including those involved in glutathione (GSH) synthesis, crucial for maintaining cellular homeostasis (55, 56)