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showed that MMI + antioxidants (83 ug selenomethionine + 17 ug Se yeast + vitamin D) treatment for 6 months improved thyroid activity more effectively than MMI use that alone ( Although the current findings are ambiguous and evidence from clinical trials does not favor the use of Se as a routine treatment option in GD, nor does the use of Se supplementation affect the remission and recurrence rates of GD ( 3.1.2 The role of Se in GO Current studies suggest that fibroblasts are distributed in the posterior globular connective tissue and ocular myofilament