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Mispairing C57BL/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injury

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In these studies, the applied dose of antidepressants was higher than those used in pain conditions such as FM

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Its resistance to gastric degradation relative to other peptides of similar length has been studied in rodent models

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