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This selectivity is one reason it is frequently referenced in academic discussions around endocrine signalling

162 Neoplasms tend to be weakly positive for antibodies to S100 protein in only a minority of cases (38%), and cytokeratin (CK) preparations are negative

[35] While there is some evidence that estrogen may play a role in the cause of BPH, this effect appears to be mediated mainly through local conversion of androgens to estrogen in the prostate tissue rather than a direct effect of estrogen itself

The SURMOUNT-4 trial showed that stopping tirzepatide after 36 weeks of maximum-dose treatment led to approximately 14% weight regain, while continuing the medication produced an additional 5.5% loss