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Clinical studies have shown that lokivetmab can significantly relieve itch within 24 hours of administration, with a 2 mg/kg dose maintaining efficacy for approximately 1 month and reducing pruritus visual analog scale (PVAS) scores by more than 50% (147, 148)

Simpler, rhythmic acoustic parts allowed a focus on Mitchell's voice and emotions ("All I Want", "A Case of You"), while others such as "Blue", "River" and "The Last Time I Saw Richard" were sung to her rolling piano accompaniment