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Bioinformatics analysis indicated that the riboflavin deficiency caused an up-regulation of Parkinsons disease pathway, steroid catabolism, endoplasmic reticulum stress and apoptotic process, while the fatty acid metabolism, tricarboxylic citrate cycle, oxidative phosphorylation and iron metabolism were down-regulated

This interaction may affect the expression of genes associated with the synthesis, release, or control of GI hormones

178,179,180 In 2004, the FDA approved the first aptamer drug, pegaptanib (Macugen), to treat choroidal neovascularization caused by neovascular age-related macular degeneration (AMD)

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