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Nevertheless, considering the demographic shift towards a progressively aging population worldwide, an even more health-focused approach must be pursued to not only prevent a collapse of the healthcare system but also other socioeconomic structures

Its not simply the kidneys "slowing down", its a multifaceted process involving: Chronic inflammation Fibrosis (scar tissue replacing healthy kidney cells) Vascular damage Autoimmune triggers Oxidative stress Reduced regenerative capacity Until now, the primary goal of treatment has been preservation, not restoration

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Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV (2015) Nephron organoids derived from human pluripotent stem cells model kidney development and injury