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However, this natural response can be slow, especially as we age or when dealing with significant tissue damage

During the subacute phase of the pathology, lactate can be utilized as an alternative energy source by some surviving neurons and astrocytes, while concurrently promoting angiogenesis and tissue repair through receptor-mediated signaling (129)

Moreover, its benefits vary, and safety (especially when it comes to IV use) is uncertain and concerning

However, clinical application of these enzymes is usually hindered by common problems including allergy to these foreign proteins, off-target cytotoxicity, short half-life and rapidly emerging chemoresistance