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Side-by-side comparison between a recombinant WT IgG1 Fc fragment and a recombinant analog of efgartigimod (IgG1 Fc fragment with MST/HN) revealed that the binding of MST/HN IgG1 Fc at pH 7.4 (KD of ~1220 nM) is approximately 5-fold weaker than that exhibited by WT IgG1 Fc at pH 6.0 (KD of ~272 nM) [225]

As shown in the Figure above, at the end of a month, weekly nasal administration results in significantly higher serum Vitamin B12 levels than after intramuscular administration

adult population (aged more than 18 years)

278 This study involves the Norwegian population and does not use the exact clinical staging system presented in the overview