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To summarize the respective roles of the CUTE proteins, Pitx1 confers pituitary specificity in the broadest sense, Tpit confers the POMC lineage identity common to corticotrophs and melanotrophs, whereas NeuroD1 expression confers corticotroph identity (4)

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An expression of concern can precede a retraction, but suggests that the editors are seriously worried about something being wrong with the publication