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It activates both GLP-1 and glucagon receptors, with the glucagon component being particularly relevant for hepatic fat metabolism -- a key differentiator that has driven its MASH development program

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Different chemopreventative approaches have been sought to interfere with initiation and control malignant progression

The logic: cagrilintide adds amylin satiety, so the same hunger control can sometimes be reached with a lower retatrutide dose, which may reduce dysesthesia and GI side effects