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Unknown Long-Term Effects : Long-term risks remain unclear because controlled human studies have not established durable safety outcomes, organ effects, cancer-related concerns, or interaction risks

This includes: Patients with malabsorption issues due to gastrointestinal disorders Individuals with pernicious anemia or other conditions that impair B12 absorption Cases where a rapid increase in B12 levels is necessary In these cases, IV delivery gets B12 straight into the blood

This method bypasses the oral route where medicines and supplements often are not capable of being fully absorbed and used by the body

As the amount of the remaining drug in F 6 without any additives was about 40 percent (Table 2), these findings showed that the presence of additives in those has destabilized vitamin B 12 and according to Table 1, PEG and PG 50% v/v as solubilizing and tonicity-adjusting agents, EDTA 0.05% w/v as a chelating agent, S.M.O 0.025%v/v as a surfactant and S.F.S 10% w/v as an antioxidant cannot be considered as stabilizing agents in the case of this study