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12 Although these compounds are beneficial in the free form, it was also confirmed that when bound to lens proteins, as occurs with increasing age in the lens nucleus, these UV filters become stronger photosensitizers which can, in the presence of oxygen and UV radiation, generate singlet oxygen, superoxide anion, and hydrogen peroxide within the lens nucleus 24 Hydrogen peroxide, although producing little direct damage, can be converted into highly reactive and damaging species in the presence of transition metals

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Although the decrease in GSH alone is not responsible for the degeneration of glial cells and neurons, reduced GSH could increase the susceptibility to other stressful factors and contribute to neuronal damage at glia and neuron cells

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