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Widespread decrease of cerebral vimentin-immunoreactive astrocytes in depressed suicides

To strengthen the evidence base, future research should adhere to rigorous methodological standards, including well-defined eligibility criteria, stratification of participants by tinnitus type and duration, standardized intervention protocols, use of validated outcome measures, adequate sample size calculation, and extended follow-up to evaluate sustained effects

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This allele has been associated with DNA methylation 35 , which might be down-regulating the GSTP1 gene expression 36