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As previously reported, the transcellular Ca 2+ movement involves the participation of transient receptor potential vanilloid type 6 (TRPV6) and transient receptor potential vanilloid type 5 in the step across the brush border membrane from enterocytes, calbindin D 9k (CB D 9k ) as a ferry from one pole to the other pole of the cells and the plasma membrane Ca 2+ -ATPase (PMCA 1b ) and the Na + /Ca 2+ exchanger (NCX1) for cation extrusion[11]

These investigators studied Type 2 diabetic patients with small-fiber neuropathy after 12 wks of administration of the antiepileptic drug topiramate and documented an increase in cutaneous nerve fiber length at multiple biopsy sites and in nerve fiber density in the proximal leg

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The structural analysis of the monomeric A