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As of June 2026, the FDA's December 2024 Pharmacy Compounding Advisory Committee evaluation concluded that the criteria weighed against placing AOD-9604 (free base) or AOD-9604 acetate on the 503A Bulks List, and AOD-9604 is currently listed as Nominated but Withdrawn from FDA Category 2

Author contributions XZ contributed to sample and data collection, performed the statistical analysis, interpreted the results, and wrote the manuscript

While we are still a long way away from pinpointing an analogous pathogenic species in MS, once identified, a specific immunotherapy targeting the relevant misfolded proteins, rather than downstream immune effectors as is the current approach, could be more effective in the progressive stages of MS