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Pristine graphene directly triggers the enhanced secondary response to the TLR-activating stimuli in bone-marrow-derived macrophages (BMDMs) by increasing the production of inflammatory cytokines ( e.g

In liver cancer, caraglipzin (CANA) can reduce aerobic glycolysis in HCC by targeting pyruvate kinase M2 (PKM2)

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This is followed by the formation of ionic edema as a result of an extracellular ionic and water level decrease, creating new gradients between plasma and interstitial fluid and driving trans-capillary fluxes of ions and osmotically obligated water