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The Leerink analysts expect CagriSema to demonstrate best-ever weight loss any day now, adding that we expect at least high-20% weight loss. Still, CagriSema could pose practical challenges for Novo, particularly in terms of commercialization

Interestingly, Larson and colleagues demonstrated that CGRP is expressed ectopically in mucus cells of ovalbumin (OVA)-sensitized Brown-Norway rats [150]

This stabilized form resists gastric acids to enable oral bioavailability while maintaining the therapeutic function of the original peptide [9]

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