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H 2 S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine

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In one specific embodiment of the auris-acceptable controlled-release formulations described herein, the active agent is provided in a gel matrix, also referred to herein as auris-acceptable gel formulations, auris interna-acceptable gel formulations, auris media-acceptable gel formulations, auris externa-acceptable gel formulations, auris gel formulations, or variations thereof