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Description

This disrupts the balance of mitochondrial regulation mechanisms due to their strong connection with the guts microbial community ( SLC25A28 (mitoferrin 2), VARS (valine-tRNA ligase), and RNF5 (E3 ubiquitin ligase)

Lifespan changes have been reported in flies and selected mouse models

10.1073/pnas.82.20.7111 Proc

This expansion was accompanied by an upregulation of the cytokines interleukin-2 (IL-2), interleukin-4 (IL-4), and interleukin-10 (IL-10) in colonic tissues