Fujimoto J, Chow CW, Zhang J, Behrens C, Moran C, Little LD, Gumbs C, Antonoff MB, Vaporciyan AA, Swisher SG , Heymach JV, Lee JJ, Hong WK, Wistuba II, Futreal A
Four hours after transfection, cells were incubated with a concentration range of TLC-2716 and TLC-6665 for 16 h, after which they were lysed, and luciferase activities were measured sequentially in the same cell extract using a BMG luminometer
K.BaehreckeE
Moreover, it was demonstrated that T-2 toxin induced cytotoxicity in HeLa cells is mediated by generation of ROS leading to DNA damage and trans activation of p53 protein expression which leads to shift in the ratio of Bax/Bcl-2 in favour of apoptosis and subsequent release of Cyt-c from mitochondria followed by caspase cascade [99]