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FIGURE 5 Berberine nanoparticles ameliorate the hepatic pro-oxidant load in the GDM rats To further evaluate the effect of the high and low doses of berberine nanoformulations on oxidative stress, the concentrations of NO and MDA, as well as the activity of pro-oxidant enzyme MPO, were measured in the liver tissue at GD19

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3A, B), concurrently with the upregulation of SQSTM1/p62 protein expression (Fig