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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, thereby being roughly four times higher than those in normal rats
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If the pleiotropic effect class is confirmed for the triple agonist, there is a potential amplification of these benefits via the glucagon lever