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Notably, this combination exerts additive or synergistic actions by targeting distinct neuroendocrine pathways: cagrilintide modulates homeostatic and hedonic food regulation centers in the hindbrain and hypothalamus, while semaglutide engages central and peripheral GLP-1 pathways to reduce calorie intake and improve glycemic regulation

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The protocol from Celsis for assessing microsomal- dependent drug metabolism was followed with minor adaptations

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National Institutes of Health

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