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Mitochondrial ROS and Apoptosis, in Mitochondrial Mechanisms of Degeneration and Repair in Parkinsons Disease

[4] Beyond collagen, GHK-Cu stimulates elastin, glycosaminoglycans, and small proteoglycans

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Copper Chelation and Delivery At the most fundamental level, GHK functions as a copper chelator and delivery system - the tripeptide binds Cu with exceptionally high affinity (binding constant approximately 10 M, among the highest known for biological copper chelators), forming a square planar coordination complex where the copper ion is coordinated by the nitrogen atoms of the terminal amino group, the two peptide bonds, and the imidazole nitrogen of histidine