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Mechanistically, SLC6A14 expression is regulated by the Wnt signaling pathway, and genetic or pharmacological inhibition of the transporter and its downstream effectors suppresses the growth of CRC cells both in vitro and in vivo 102

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7 MDS-related TOD including macrovascular diseases and microvascular complications, such as chronic kidney disease (CKD), retinopathy, neuropathy, along with diabetic foot ulcerations (DFU), are responsible for much of the burden associated with diabetes

Mechanistic insights reveal that reduced activity of phosphatidylcholine (lecithin)-cholesterol acyltransferase (LCAT) in MDD impairs cholesterol esterification, diminishing HDL maturation and RCT efficiency (72)