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Rosuvastatin was negative in the in vivo mouse micronucleus test

It has been widely postulated that this hangxiety occurs as a result of rebound changes in brain chemistry

Some chelators, such as D-penicillamine, also cause direct neurotoxicity, likely by crossing the blood-brain barrier and disrupting copper-dependent central nervous system enzymes, impairing energy metabolism, and increasing oxidative stress [245, 246]