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Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term studies in animals to evaluate carcinogenic potential have not been done

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Dosage: Individualize dosing based on the patients specific medical condition and B12 concentration level in the body

No studies have directly evaluated the cardiovascular effects of correcting vitamin B 12 deficiency in patients with known cardiovascular disease, although numerous studies have failed to demonstrate that correction of hyperhomocysteinemia itself reduces cardiovascular mortality or cardiovascular complications