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Originally developed for type 2 diabetes management, these medications have been authorised for weight management in individuals with obesity or those who are overweight with weight-related health conditions

In sharp contrast, 5 out of 6 domains of HGF I, including N, K1, K2, K3, and SPH domains, make direct contacts with either c-MET I-SEMA or c-MET II-SEMA, burying 61, 1141, 509, 665, and 962 2 surface area, respectively

Consistent with this, AMPK deletion decreases the activation of AKT and promotes M1 macrophage polarization [89]

Nat Rev Nephrol 17:417433 Ye Y, Chen A, Li L, Liang Q, Wang S, Dong Q (2022) Repression of the antiporter SLC7A11/glutathione/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification