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Previous reports have shown that relatively high levels of mTOR complex 1 (mTORC1) signaling prevail in MZB 36,37 , but that the maturation of FoB downregulates the mTORC1/Akt pathway 38

Using our single-cell mass cytometry approach, which allows us to detect CAR T cells in the context of the broader cellular BM background, we compared changes in metabolic protein expression over time between the pre-infusion products and the day 28 BM samples of the two cohorts

To account for this, the repeated measures approach controlled for individual variation in our analyses

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