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It increases the risk for multiple metabolic complications including type 2 diabetes (T2D), metabolic-dysfunction associated steatotic liver disease (MASLD, previously known as non-alcoholic fatty liver disease), cardiovascular disease as well as many mechanical complications such as osteoarthritis and obstructive sleep apnoea (OSA) [3]

Principle: Endotoxins are lipopolysaccharides (LPS) from the outer membrane of Gram-negative bacteria

The TRIUMPH-1 readout is the one researchers should watch most closely, because it will define the label-level weight-loss claim and because it is the trial that anchors the regulatory submission

- Assists in maintaining a strong immune response